史向阳

史向阳

东华大学教授

史向阳，1970年8月生，东华大学化学化工与生物工程学院生物科学与技术研究所教授，博士生导师，校特聘教授，上海高校特聘教授（东方学者）。

2008年回国前，在美国密西根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。美国化学会、中国化学会、中国生物材料委员会会员，上海市生物物理学会理事，美国密西根大学医学和生物科学纳米技术研究所客座研究员，首届葡萄牙马德拉大学“邀请纳米技术主任（Invited Chair in Nanotechnology）。是Current Nanoscience、American Journal of Nanotechnology、Advances in Nano Research, An International Journal、Journal of Modern Textile Science and Engineering等期刊编委，也是Nat. Nanotechnol.、Nat. Commun.和 J. Am. Chem. Soc.等84个国际杂誌审稿人。

    • 中文名：史向阳
    • 职业：教授
    • 单位：东华大学化学化工与生物工程学院

研究方向

1.生物纳米技术：以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台，研究各种癌症的早期诊断和治疗。

2.新型纳米材料和纳米複合材料的合成、组装、表面修饰、性能、及其在生物医学中的套用。

3.静电纺纳米纤维在生物医学和环境科学中的套用。

荣誉及获奖情况

1. 2008年6月获上海高校特聘教授（东方学者）称号；

2. 2009年入围首批SCOPUS寻找未来科学之星活动全国纳米科学前10名；

3. 2010年获首届葡萄牙马德拉大学“邀请纳米技术主任（Invited Chair in Nanotechnology）”称号；

4. 2011年获教育部“新世纪优秀人才”支持计画；

5. 2013 年获上海高校特聘教授（东方学者）跟蹤支持计画；

6. 2014年，第五届中国侨界贡献奖创新人才奖。

7. 2014年，中国纺织工程学会第15届陈维稷优秀论文奖。

主持与承担主要项目情况

  1. 利用树状大分子纳米技术构建多功能纳米杂化颗粒及其肿瘤CT/MRI双模态成像诊断研究，国家自然科学基金面上项目 (项目批准号：21273032)，2013.1-2016.12，项目主持人，在研。

  2. 多功能树状大分子包裹的纳米金颗粒作为平台用于癌细胞的CT成像研究，国家自然科学基金面上项目 (项目批准号：20974019)，2010.1-2012.12，项目主持人，结题。

  3. 多功能杂化纳米水凝胶及其双模态分子影像学套用，中德科学基金研究交流中心(GZ899)，2013.10-2016.9，项目主持人，在研。

  4. 树状大分子纳米材料及其医学套用，教育部新世纪人才支持计画，2012.1 -2014.12，项目主持人，结题。

  5. 多功能树状大分子包裹的纳米金颗粒作为肿瘤CT成像造影剂的研究，上海市科委浦江人才计画（09PJ1400600），2009.7-2011.7，项目主持人，结题。

  6. 多功能磁性氧化铁/金核壳纳米探针的构建及其分子影像诊断套用，上海市科委纳米专项（11nm0506400），2011.12 -2014. 9，项目主持人, 结题。

  7. 基于树状大分子的多功能肿瘤成像造影剂的研究, 上海高校特聘教授（东方学者）奖励计画，2008.6-2011.6，项目主持人，已结题。

  8. 纳米生物医用材料与技术，上海高校特聘教授（东方学者）跟蹤计画支持， 2014.1-2016.12，项目主持人，在研。

  9. 葡萄牙马德拉大学“邀请纳米技术主任”基金 (由葡萄牙科技部FCT和Santander 银行资助) ，项目主持人，2010-2018，在研。

  10. DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors，葡萄牙科技部 (FCT)项目（PTDC/CTM-NAN/1748/2012）, 2013.4-2015.4, 项目主持人，结题。

  11. 人工纳米生物机器构筑与生物医学套用的基础研究，973计画（2007CB936000），2007.7-2011.8，参与，已结题。

  12. 有机/无机纳米複合修复材料及其口腔医学套用开发，国家高技术研究发展计画 (2012AA030309)，2012.1-2014.12，参与，已结题。

发表论着情况

史向阳教授的主要研究成果包括在纳米医学与生物技术、纳米科学、材料化学、高分子化学和分析化学等领域内共发表或接受发表了269篇期刊论文，10篇书的章节，和228篇会议论文、摘要或报告，并获授权中国发明专利57项。研究工作发表在Chem. Rev., Prog. Polym. Sci., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Small, Adv. Funct. Mater.和Biomaterials等等专业杂誌上。其中SCI收录的论文有242篇，影响因子超过3.0以上的文章有182篇，影响因子超过7.0以上的文章有55篇。文章总引用数超过8282次，单篇引用最高次数为362次，H-index为51。

2011年以来发表的代表论着：

1. Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang*. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2011, 32, 2979-2988 (impact factor 8.387, citation #120).

2. Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen, Xiangyang Shi*. Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials 2011, 32, 3322-3329 (citation #110, impact factor 8.387).

3. Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and Xiangyang Shi*. Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction. Nanoscale 2011, 3 (4), 1741-1747. (impact factor 7.760, citation #27).

4. Hong Yang, Yeming Zhuang, Yun Sun, Antao Dai, Xiangyang Shi,* Dongmei Wu, Fuyou Li, He Hu and Shiping Yang*. Targeted Dual Contrast T1- and T2-weighted Magnetic Resonance Imaging of Tumors using Multifunctional Gadolinium-Labeled Superparamagnetic Iron Oxide Nanoparticles. Biomaterials 2011, 32 (20), 4584-4593 (citation #108, impact factor 8.387).

5. Chen Peng, Linfeng Zheng, Qian Chen, Mingwu Shen, Rui Guo, Han Wang, Xueyan Cao, Guixiang Zhang,* Xiangyang Shi*. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 2012, 33, 1107-1119 (impact factor 8.387, citation #153).

6. Yuebin Shan, Ting Luo, Chen Peng, Ruilong Sheng, Amin Cao,* Xueyan Cao, Mingwu Shen, Rui Guo, Helena Tomás, Xiangyang Shi*. Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials 2012, 33, 3025-3035 (impact factor 8.387, citation #91).

7. Yunpeng Huang, Hui Ma, Shige Wang, Mingwu Shen,* Rui Guo, Xueyan Cao, and Xiangyang Shi*. Efficient catalytic reduction of hexavalent chromium using palladium nanoparticle-immobilized electrospun polymer nanofibers. ACS Appl. Mater. Interfaces 2012, 4(6), 3054-3061 (impact factor 7.145, citation #43).

8. Chen Peng, Kangan Li, Xueyan Cao, Tingting Xiao, Wenxiu Hou, Rui Guo, Mingwu Shen, Guixiang Zhang**, and Xiangyang Shi*. Facile Formation of Dendrimer-Stabilized Gold Nanoparticles Modified with Diatrizoic Acid for Enhanced Computed Tomography Imaging Applications. Nanoscale 2012, 4 (21), 6768 - 6778 (impact factor 7.760, citation #36, back cover of the issue).

9. Shige Wang, Fuyin Zheng, Yunpeng Huang, Yuting Fang, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. Encapsulation of Amoxicillin within Laponite-Doped Poly(lactic-co-glycolic acid) Nanofibers: Preparation, Characterization and Antibacterial Activity. ACS Appl. Mater. Interfaces 2012, 4, 6393−6401 (impact factor 7.145, citation #48).

10. Han Wang, Linfeng Zheng, Chen Peng, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang.* Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma. Biomaterials 2013, 34, 470-480 (impact factor 8.387, citation #68).

11. Fuyin Zheng, Shige Wang, Shihui Wen, Mingwu Shen,** Meifang Zhu, Xiangyang Shi*. Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. Biomaterials 2013, 34, 1402-1412 (impact factor 8.387, citation #59).

12. Shihui Wen, Kangan Li, Hongdong Cai, Qian Chen, Yunpeng Huang, Chen Peng, Mingwu Shen, Guixiang Zhang*,and Xiangyang Shi*. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Dual Mode CT/MR Imaging Applications. Biomaterials 2013, 34, 1570-1580 (impact factor 8.387, citation #99).

13. Hongdong Cai, Xiao An, Jun Cui, Jingchao Li, Shihui Wen, Kangan Li, Mingwu Shen*, Linfeng Zheng, Guixiang Zhang*, Xiangyang Shi*. Facile Hydrothermal Synthesis and Surface Functionalization of Polyethyleneimine-Coated Iron Oxide Nanoparticles for Biomedical Applications. ACS Appl. Mater. Interfaces 2013, 5 (5), 1722–1731 (impact factor 7.145, citation #71).

14. Qian Chen, Kangan Li , Shihui Wen, Hui Liu, Chen Peng, Hongdong Cai, Mingwu Shen, Guixiang Zhang**, Xiangyang Shi*. Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials 2013, 34, 5200-5209 (impact factor 8.387, citation #77).

15. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* and Xiangyang Shi*. Polyethyleneimine-Mediated Synthesis of Folic Acid-Targeted Iron Oxide Nanoparticles for in Vivo Tumor MR Imaging. Biomaterials 2013, 34, 8382-8392 (impact factor 8.387, citation #84).

16. Jingchao Li, Linfeng Zheng, Hongdong Cai, Wenjie Sun, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Facile One-Pot Synthesis of Fe3O4@Au Composite Nanoparticles for Dual Mode MR/CT Imaging Applications. ACS Appl. Mater. Interfaces 2013, 5(20), 10357-10366 (impact factor 7.145, citation #39).

17. Dengmai Hu, Yunpeng Huang, Hui Liu, Hong Wang, Shige Wang, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. TheAssembly of Dendrimer-Stabilized Gold Nanoparticles onto Electrospun Polymer Nanofibers for Catalytic Applications. J. Mater. Chem. A 2014, 2, 2323–2332 (Impact factor 8.262).

18. Jingchao Li, Yao He, Wenjie Sun, Hongdong Cai, Yunqi Pan, Mingwu Shen**, Jindong Xia***, Xiangyang Shi*. Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging. Biomaterials 2014, 35, 3666-3677 (impact factor 8.387, citation #75).

19. Shige Wang, Jingyi Zhu, Mingwu Shen, Meifang Zhu, Xiangyang Shi*. Poly(amidoamine) Dendrimer-Enabled Simultaneous Stabilization and Functionalization of Electrospun Poly(γ-glutamic acid) Nanofibers. ACS Appl. Mater. Interfaces 2014, 6, 2153−2161 (impact factor 7.145, citation # 9).

20. Hui Liu+, Han Wang+, Yanhong Xu, Mingwu Shen, Jinglong Zhao, Guixiang Zhang*, Xiangyang Shi*. Synthesis of PEGylated Low Generation Dendrimer-Entrapped Gold Nanoparticles for CT Imaging Applications. Nanoscale 2014, 6(9), 4521-4526 (impact factor 7.760, citation #27).

21. Hui Liu+, Han Wang+, Yanhong Xu+, Rui Guo, Shihui Wen, Yunpeng Huang, Weina Liu, Mingwu Shen*, Jinglong Zhao, Guixiang Zhang*, and Xiangyang Shi*. Lactobionic Acid-Modified Dendrimer-Entrapped Gold Nanoparticles for Targeted CT Imaging of Human Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces 2014, 6, 6944−6953 (impact factor 7.145, citation # 29).

22. Jingyi Zhu, Linfeng Zheng, Shihui Wen, Yueqin Tang, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*.Targeted Cancer Theranostics Using Alpha-Tocopheryl Succinate-Conjugated Multifunctional Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2014, 35, 7635-7646 (impact factor 8.387, citation #42).

23. Kai Li, Shige Wang, Shihui Wen, Yueqin Tang, Jipeng Li, Xiangyang Shi,* and Qinghua Zhao*. Enhanced In Vivo Antitumor Efficacy of Doxorubicin Encapsulated within Laponite Nanodisks. ACS Appl. Mater. Interfaces 2014, 6, 12328−12334 (impact factor 7.145, citation # 14).

24. Guoying Wang, Dina Maciel, Yilun Wu, João Rodrigues, Xiangyang Shi, Yuan Yuan, Changsheng Liu, Helena Tomás,* Yulin Li*. Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery. ACS Appl. Mater. Interfaces 2014, 6, 16687−16695 (impact factor 7.145, citation #15). Non-corresponding author.

25. Fanfan Fu, Jingyi Zhu, Shihui Wen, Mingwu Shen, Xiangyang Shi*. Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: Investigating the role played by PEG spacer. ACS Appl. Mater. Interfaces 2014, 6, 16416−16425 (impact factor 7.145, citation # 25).

26. Benqing Zhou, Linfeng Zheng, Chen Peng, Du Li, Jingchao Li, Shihui Wen, Mingwu Shen*, Guixiang Zhang*, Xiangyang Shi*. Synthesis and characterization of PEGylated polyethyleneimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl. Mater. Interfaces 2014, 6, 17190−17199 (impact factor 7.145, citation #21).

27. Jingchao Li, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,* Guixiang Zhang,* Xiangyang Shi*. Hyaluronic Acid-Modified Fe3O4@Au Core/shell Nanostars for Multimodal Imaging and Photothermal Therapy of Tumors. Biomaterials 2015, 38, 10-21 (impact factor 8.387, citation #56).

28. Lingdan Kong, Carla S. Alves, Wenxiu Hou, Jieru Qiu, Helmuth Möhwald, Helena Tomás,* Xiangyang Shi*. RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells. ACS Appl. Mater. Interfaces 2015, 7 (8), 4833-4843 (impact factor 7.145, citation #18).

29. Jia Yang, Yu Luo, Yanhong Xu, Jingchao Li, Zaixian Zhang, Han Wang, Mingwu Shen, Xiangyang Shi,* Guixiang Zhang*. Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging. ACS Appl. Mater. Interfaces 2015, 7(9), 5420-5428 (impact factor 7.145, citation #7).

30. Yu Luo, He Shen, Yongxiang Fang, Yuhua Cao, Jie Huang, Mengxin Zhang, Jianwu Dai,* Xiangyang Shi,* and Zhijun Zhang*. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl. Mater. Interfaces 2015, 7 (11), 6331–6339 (impact factor 7.145, citation #17).

31. Zheng Qiao, Xiangyang Shi*. Dendrimer-based molecular imaging contrast agents. Prog. Polym. Sci. 2015, 44, 1–27 (Impact factor 27.184, citation #18).

32. Yu Luo, Jia Yang, Yu Yan, Jingchao Li, Mingwu Shen,* Guixiang Zhang,* Serge Mignani, Xiangyang Shi*. RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of glioma. Nanoscale 2015, 7, 14538–14546 (impact factor 7.760, citation #12).

33. Hongdong Cai, Kangan Li, Jingchao Li, Shihui Wen, Qian Chen, Mingwu Shen,* Linfeng Zheng, Guixiang Zhang,* Xiangyang Shi*. Dendrimer-Assisted Formation of Fe3O4/Au Nanocomposite Particles for Targeted Dual Mode CT/MR Imaging of Tumors. Small 2015, 11 (35), 4584-4593 (impact factor 8.315, citation #13).

34. Yulin Li*, Dina Maciel, João Rodrigues*, Xiangyang Shi*, Helena Tomás*. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chem. Rev. 2015, 115 (16), 8564–8608 (impact factor 37.369, citation #18).

35. Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi*, and Jinhua Zhao*. Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide I for SPECT Imaging and Radiotherapy of Gliomas. ACS Appl. Mater. Interfaces 2015, 7 (35), 19798–19808 (impact factor 7.145, citation #3).

36. Jingyi Zhu, Lingzhou Zhao, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Mingwu Shen, Jinhua Zhao,* and Xiangyang Shi*. Radionuclide I-Labeled Multifunctional Dendrimers for Targeted SPECT Imaging and Radiotherapy of Tumors. Nanoscale 2015, 7, 18169-18178 (impact factor 7.760, citation #1).

37. Yongxing Zhang, Shihui Wen, Lingzhou Zhao, Du Li, Changcun Liu, Wenbin Jiang, Xiang Gao, Wentao Gu, Nan Ma, Jinhua Zhao*, Xiangyang Shi*, Qinghua Zhao*. Ultrastable polyethyleneimine-stabilized gold nanoparticles modified with polyethylene glycol for blood pool, lymph node and tumor CT imaging. Nanoscale 2016, 8, 5567–5577 (impact factor 7.760, citation #1).

38. Jingwen Chen, Yingqi Sun, Qian Chen, Le Wang, Suhe Wang, Yun Tang,* Xiangyang Shi*, Han Wang*. Multifunctional gold nanocomposites designed for targeted CT/MR/optical tri-modal imaging of human non-small cell lung cancer cells. Nanoscale 2016, 8, 13568–13573 (impact factor 7.760).

39. Xin Li, Zuogang Xiong, Xiaoying Xu, Yu Luo, Chen Peng*, Mingwu Shen*, and Xiangyang Shi*. 99mTc-Labeled Multifunctional Low Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT/CT Dual-Mode Imaging of Tumors. ACS Appl. Mater. Interfaces 2016, 8, 19883-19891 (impact factor 7.145).

40. Aijun Li, Benqing Zhou, Bei Xu, Rui Guo, Xiangyang Shi,* Xueyan Cao*. Mechanistic Studies of the Enhanced PCR Using PEGylated PEI-Entrapped Gold Nanoparticles. ACS Appl. Mater. Interfaces 2016, 8 (39), 25808–25817 (impact factor 7.145).

国际交流与合作

美国密西根大学（University of Michigan, Ann Arbor），美国乔治亚大学格里芬分校（University of Georgia, Griffin），美国伊利诺伊大学芝加哥分校（University of Illinois at Chicago），葡萄牙马德拉大学 (Universidade da Madeira)，匈牙利徳布勒森大学（University of Debrecen），德国亚琛工业大学（RWTH Aachen），法国国家科学院（CNRS）。

主讲课程

纳米医学 (博士研究生课程)，化学前沿（博士研究生课程），纳米医学与生物技术（功能材料专业生物材料方向本科生课程）。

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